Ernst Wolfgang Caspari was an important contributor to behavior and developmental genetics, working primarily on the mealmoth Ephestia. Trained in Alfred Kuhn's laboratory at the University of Göttingen (1933-1935), Caspari was forced from his position by the Nazis in 1933, escaping to the United States five years later. As a professor of biology at Lafayette College, Wesleyan University, and the University of Rochester, Caspari continued his research on Ephestia, mouse genetics, and behavior genetics until his retirement in 1975. The Caspari Papers includes correspondence, papers, grant reports, and lectures relating to Caspari's genetic research dating primarily from the period after his departure from Germany. In addition to substantial material on behavior genetics and human evolution, the collection includes correspondence relating to Caspari's editorial work for Advances in Genetics, and his involvement with the American Institute of Biological Sciences, the Center for Advanced Study in the Behavioral Sciences, Cold Spring Harbor Laboratory, Fifth Banff Conference on Theoretical Psychology, Genetics Society of America, International Conference on the Unity of Science, Social Science Research Council, Committee on Genetics and Behavior, and the U.S. Atomic Energy Commission.

Sewall Wright ranks among the most influential figures in the field of population genetics during the 20th century, and made important contributions to biostatistics, biometrics, and evolutionary theory. These papers contain much of Wright's professional correspondence, scattered research notes, and drafts of a small number of papers.